Compound Detail
CHEMBL5203383
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Basic Information
| ChEMBL ID | CHEMBL5203383 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VMDZCGSWWDTUMR-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
249.3
MW (Da)
0.55
ALogP
4
HBA
2
HBD
55.8
PSA (Ų)
0.61
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.37
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Polyamine deacetylase HDAC10 CHEMBL4802002 | IC50 | 7.37 | 7.37 | 43.0 | 1 |
| Histone deacetylase 6 CHEMBL1865 | IC50 | 6.55 | 6.55 | 280.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Polyamine deacetylase HDAC10 | IC50 | = | 43.0 | nM | 7.37 | Inhibition of zebra fish HDAC10 using Ac-spermidine-AMC as substrate incubated f... | 35306288 |
| Histone deacetylase 6 | IC50 | = | 280.0 | nM | 6.55 | Inhibition of recombinant human HDAC6 using ZMAL (Z-(Ac)Lys-AMC as substrate inc... | 35306288 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35306288 | 10.1016/j.ejmech.2022.114272 | Histone deacetylase 1 | 2 |
| 35306288 | 10.1016/j.ejmech.2022.114272 | Polyamine deacetylase HDAC10 | 1 |
| 35306288 | 10.1016/j.ejmech.2022.114272 | Histone deacetylase 6 | 1 |
| 35306288 | 10.1016/j.ejmech.2022.114272 | HEK293 | 1 |
Data from ChEMBL 36 via Core Engine