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Target Snapshot

CHEMBL4802002 Target Snapshot

Polyamine deacetylase HDAC10 · SINGLE PROTEIN · Danio rerio

17Compounds
4Assays
0Approved Drugs
14.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt F1QCV2. Use UniProt F1QCV2 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt F1QCV2 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Polyamine deacetylase HDAC10 as ChEMBL target CHEMBL4802002, mapped to UniProt F1QCV2. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Polyamine deacetylase HDAC10
SINGLE PROTEIN · Danio rerio
As of 2026-09-14
ChEMBL target ID
CHEMBL4802002
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
F1QCV2
Polyamine deacetylase HDAC10
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Polyamine deacetylase HDAC10 is the right protein anchor across sources, using UniProt F1QCV2 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPolyamine deacetylase HDAC10
UniProt AccessionF1QCV2
Component TypeProtein
Sequence Length675 aa

Polyamine deacetylase HDAC10

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Polyamine deacetylase HDAC10, mapped to UniProt F1QCV2. Sequence length is 675 aa.

Mapped IDF1QCV2
Review namePolyamine deacetylase HDAC10
OrganismDanio rerio
Assay Mix

Activity Type Distribution

IC5014.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5184156 7.96 IC50 11.0 Preclinical
CHEMBL5173958 7.7 IC50 20.0 Preclinical
CHEMBL5208990 7.62 IC50 24.0 Preclinical
CHEMBL5207713 7.54 IC50 29.0 Preclinical
CHEMBL5188463 7.48 IC50 33.0 Preclinical
CHEMBL5181507 7.43 IC50 37.0 Preclinical
CHEMBL5203383 7.37 IC50 43.0 Preclinical
CHEMBL5201275 7.24 IC50 58.0 Preclinical
CHEMBL5176967 7.22 IC50 60.0 Preclinical
CHEMBL5184762 7.21 IC50 62.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
1
6.0
3
6.5
6
7.0
4
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

4
Total Assays
14
Tested Compounds
1
Assay Types
Binding — 4 assays, 14 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 3 13 7.3
cell-based format 1 1 6.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine