Compound Detail
CHEMBL5176967
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Basic Information
| ChEMBL ID | CHEMBL5176967 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BZDBEVIQFLLLRU-SNAWJCMRSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
294.8
MW (Da)
2.61
ALogP
3
HBA
2
HBD
52.6
PSA (Ų)
0.51
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Polyamine deacetylase HDAC10 CHEMBL4802002 | IC50 | 7.22 | 7.22 | 60.0 | 1 |
| Histone deacetylase 8 CHEMBL3192 | IC50 | 6.33 | 6.33 | 470.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Polyamine deacetylase HDAC10 | IC50 | = | 60.0 | nM | 7.22 | Inhibition of zebra fish HDAC10 using Ac-spermidine-AMC as substrate incubated f... | 35306288 |
| Histone deacetylase 8 | IC50 | = | 470.0 | nM | 6.33 | Inhibition of recombinant human HDAC8 using H2N-Arg- His-Lys(Ac)-Lys(Ac)-AMC as ... | 35306288 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35306288 | 10.1016/j.ejmech.2022.114272 | Histone deacetylase 1 | 2 |
| 35306288 | 10.1016/j.ejmech.2022.114272 | Histone deacetylase 6 | 2 |
| 35306288 | 10.1016/j.ejmech.2022.114272 | Polyamine deacetylase HDAC10 | 1 |
| 35306288 | 10.1016/j.ejmech.2022.114272 | Histone deacetylase 8 | 1 |
| 35306288 | 10.1016/j.ejmech.2022.114272 | HEK293 | 1 |
Data from ChEMBL 36 via Core Engine