Assay Detail
Binding
CHEMBL5135826
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR phosphorylation (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The Ascension of Targeted Covalent Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.48 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2110732 | DACOMITINIB ANHYDROUS | 4.0 | 1 | 8.22 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 6.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2110732 | DACOMITINIB ANHYDROUS | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 184.0 | nM | 6.74 |