Assay Detail
Binding
CHEMBL5135835
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BTK in human whole blood
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The Ascension of Targeted Covalent Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.30 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3936761 | ZANUBRUTINIB | 4.0 | 1 | 8.62 |
| CHEMBL1873475 | IBRUTINIB | 4.0 | 1 | 8.24 |
| CHEMBL3707348 | ACALABRUTINIB | 4.0 | 1 | 8.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3936761 | ZANUBRUTINIB | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL1873475 | IBRUTINIB | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL3707348 | ACALABRUTINIB | EC50 | = | 9.2 | nM | 8.04 |