Assay Detail
Functional
CHEMBL5135904
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Antiviral activity against HCoV-229E infected in HEL 299 cells assessed as reduction in virus-induced cytopathic effect preincubated with compound followed by viral infection and measured after 7 days by MTS cell viability assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human coronavirus 229E |
| Cell Type | HEL 299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 5.68 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4164426 | — | — | 1 | 6.70 |
| CHEMBL4171241 | — | — | 1 | 6.52 |
| CHEMBL5202059 | — | — | 1 | 6.22 |
| CHEMBL5185967 | — | — | 1 | 6.16 |
| CHEMBL2016757 | GS-441524 | 1.0 | 1 | 6.05 |
| CHEMBL4164881 | — | — | 1 | 5.89 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 5.89 |
| CHEMBL4175717 | — | — | 1 | 5.75 |
| CHEMBL5173495 | — | — | 1 | 5.66 |
| CHEMBL4175014 | — | — | 1 | 5.54 |
| CHEMBL4168943 | — | — | 1 | 5.46 |
| CHEMBL5181347 | — | — | 1 | 5.03 |
| CHEMBL5209332 | — | — | 1 | 4.40 |
| CHEMBL2385690 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4164426 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4171241 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5202059 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5185967 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2016757 | GS-441524 | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4164881 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4175717 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5173495 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4175014 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4168943 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5181347 | — | EC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL5209332 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL2385690 | — | EC50 | = | 61300.0 | nM | 4.21 |