Assay Detail
Binding
CHEMBL5135910
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS-CoV-2 nsp13 helicase-associated activity using 5'- AGT CTT CTC CTG GTG CTC GAA CAG TGA CCy3-3', 5'- BHQ-2-GTC ACT GTT CGA GCA CCA CCT CTT CTG A-3' DNA as substrate preincubated for 10 mins followed by substrate addition and measured after 15 mins in the presence of ATP by fluorescent-based helicase unwind assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.52 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1595621 | — | — | 1 | 7.34 |
| CHEMBL4175014 | — | — | 1 | 6.38 |
| CHEMBL5181347 | — | — | 1 | 5.85 |
| CHEMBL5173495 | — | — | 1 | - |
| CHEMBL5209332 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1595621 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4175014 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5181347 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL5173495 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5209332 | — | IC50 | > | 30000.0 | nM | - |