Assay Detail
Binding
CHEMBL5136366
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Binding affinity to human N-terminal TEV cleavable 6His tagged p47phox (151-285 residues) assessed as dissociation rate constant by Surface plasmon resonance assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting NOX2 via p47/phox-p22/phox Inhibition with Novel Triproline Mimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 6.46 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5197024 | — | — | 1 | 7.37 |
| CHEMBL5205264 | — | — | 1 | 6.67 |
| CHEMBL5177721 | — | — | 1 | 6.51 |
| CHEMBL5194506 | — | — | 1 | 5.29 |
| CHEMBL5202610 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5197024 | — | Kd | = | 43.0 | nM | 7.37 |
| CHEMBL5205264 | — | Kd | = | 214.0 | nM | 6.67 |
| CHEMBL5177721 | — | Kd | = | 312.0 | nM | 6.51 |
| CHEMBL5194506 | — | Kd | = | 5170.0 | nM | 5.29 |
| CHEMBL5202610 | — | Kd | > | 30000.0 | nM | - |