Assay Detail
Functional
CHEMBL5136528
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 6.64 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4784510 | BMS-986235 | 1.0 | 1 | 8.30 |
| CHEMBL5191583 | — | — | 1 | 8.00 |
| CHEMBL5190385 | — | — | 1 | 7.50 |
| CHEMBL5201495 | — | — | 1 | 7.43 |
| CHEMBL5185842 | — | — | 1 | 7.40 |
| CHEMBL5181627 | — | — | 1 | 7.40 |
| CHEMBL5197524 | — | — | 1 | 7.28 |
| CHEMBL5169641 | — | — | 1 | 6.96 |
| CHEMBL5204580 | — | — | 1 | 6.80 |
| CHEMBL5187399 | — | — | 1 | 6.60 |
| CHEMBL5201015 | — | — | 1 | 6.60 |
| CHEMBL5208504 | — | — | 1 | 6.17 |
| CHEMBL5203364 | — | — | 1 | 6.08 |
| CHEMBL5186339 | — | — | 1 | 5.89 |
| CHEMBL5197701 | — | — | 1 | 5.66 |
| CHEMBL5204594 | — | — | 1 | 5.64 |
| CHEMBL5194850 | — | — | 1 | 5.60 |
| CHEMBL5195336 | — | — | 1 | 5.46 |
| CHEMBL5203596 | — | — | 1 | 5.43 |
| CHEMBL5180535 | — | — | 1 | - |
| CHEMBL5207660 | — | — | 1 | - |
| CHEMBL5195406 | — | — | 1 | - |
| CHEMBL5208024 | — | — | 1 | - |
| CHEMBL5174501 | — | — | 1 | - |
| CHEMBL5192360 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4784510 | BMS-986235 | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5191583 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5190385 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5201495 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5185842 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5181627 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5197524 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5169641 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5204580 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5187399 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5201015 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5208504 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL5203364 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL5186339 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5197701 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5204594 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5194850 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5195336 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5203596 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5180535 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5207660 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5195406 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5208024 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5174501 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5192360 | — | EC50 | > | 10000.0 | nM | - |