Assay Detail
Functional
CHEMBL5136529
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Agonist activity at human FPR1 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.96 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4784510 | BMS-986235 | 1.0 | 1 | 6.40 |
| CHEMBL5191583 | — | — | 1 | 6.33 |
| CHEMBL5190385 | — | — | 1 | 5.85 |
| CHEMBL5187399 | — | — | 1 | 5.26 |
| CHEMBL5186339 | — | — | 1 | - |
| CHEMBL5208504 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4784510 | BMS-986235 | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5191583 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL5190385 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5187399 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL5186339 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5208504 | — | EC50 | > | 10000.0 | nM | - |