Assay Detail
Functional
CHEMBL5136530
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Agonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migration
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.80 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4784510 | BMS-986235 | 1.0 | 1 | 8.12 |
| CHEMBL5191583 | — | — | 1 | 7.72 |
| CHEMBL5190385 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4784510 | BMS-986235 | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL5191583 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5190385 | — | IC50 | = | 28.0 | nM | 7.55 |