Assay Detail
Binding
CHEMBL5136674
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged human CDK9/Cyclin T1 expressed in Sf9 cells using (YSPTSPS)2KK peptide as substrate in presence of ATP and [gamma33-P] ATP by radioisotope filter binding assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
3,5,7-Substituted Pyrazolo[4,3-<i>d</i>]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.72 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103840 | DINACICLIB | 3.0 | 1 | 8.22 |
| CHEMBL5182767 | — | — | 1 | 7.96 |
| CHEMBL5169449 | — | — | 1 | 7.92 |
| CHEMBL5194202 | — | — | 1 | 7.70 |
| CHEMBL5187378 | — | — | 1 | 7.64 |
| CHEMBL5194833 | — | — | 1 | 7.42 |
| CHEMBL5191136 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103840 | DINACICLIB | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5182767 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5169449 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5194202 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5187378 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5194833 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5191136 | — | IC50 | = | 62.0 | nM | 7.21 |