Assay Detail
ADMET
CHEMBL5136862
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Time dependent inhibition of CYP1A2 in pooled human liver microsomes using midazolam as substrate preincubated for 30 mins in presence of NADPH followed by substrate addition and measured after 10 mins by LC-MS/MS analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.96 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5206259 | — | — | 1 | 5.96 |
| CHEMBL5208605 | — | — | 1 | 5.96 |
| CHEMBL5176687 | — | — | 1 | - |
| CHEMBL5200987 | — | — | 1 | - |
| CHEMBL5209466 | — | — | 1 | - |
| CHEMBL5188032 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5206259 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5208605 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5176687 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5200987 | — | IC50 | > | 8800.0 | nM | - |
| CHEMBL5209466 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5188032 | — | IC50 | > | 10000.0 | nM | - |