Assay Detail
Binding
CHEMBL5136914
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]alpha-bungarotoxin from human alpha7 nAChR expressed in SH-SY5Y cells membrane assessed as inhibition constant preincubated for 5 mins followed by overnight incubation with [125I]alpha-bungarotoxin by beta liquid scintilation analysis
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
From 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624) to Selective Small-Molecule Antagonists of Human α9α10 Nicotinic Receptor by Modifications at the Ammonium Ethyl Residue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 6.43 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178473 | — | — | 1 | 7.64 |
| CHEMBL5192210 | — | — | 1 | 7.47 |
| CHEMBL5177606 | — | — | 1 | 7.43 |
| CHEMBL5202770 | — | — | 1 | 7.23 |
| CHEMBL5201239 | — | — | 1 | 7.14 |
| CHEMBL5176690 | — | — | 1 | 7.10 |
| CHEMBL5190813 | — | — | 1 | 7.03 |
| CHEMBL1257065 | STILONIUM IODIDE | 2.0 | 1 | 6.98 |
| CHEMBL5200914 | — | — | 1 | 6.96 |
| CHEMBL5174508 | — | — | 1 | 6.95 |
| CHEMBL5197631 | — | — | 1 | 6.93 |
| CHEMBL5176101 | — | — | 1 | 6.79 |
| CHEMBL5176544 | — | — | 1 | 6.65 |
| CHEMBL5182114 | — | — | 1 | 6.61 |
| CHEMBL5193899 | — | — | 1 | 6.59 |
| CHEMBL5170445 | — | — | 1 | 6.55 |
| CHEMBL5191958 | — | — | 1 | 6.51 |
| CHEMBL5193143 | — | — | 1 | 6.25 |
| CHEMBL5171118 | — | — | 1 | 6.21 |
| CHEMBL5181363 | — | — | 1 | 6.20 |
| CHEMBL5182514 | — | — | 1 | 5.95 |
| CHEMBL5173112 | — | — | 1 | 5.80 |
| CHEMBL5195695 | — | — | 1 | 5.61 |
| CHEMBL5186396 | — | — | 1 | 5.48 |
| CHEMBL5184266 | — | — | 1 | 5.41 |
| CHEMBL5176875 | — | — | 1 | 5.23 |
| CHEMBL5205894 | — | — | 1 | 5.00 |
| CHEMBL5208202 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178473 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL5192210 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL5177606 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL5202770 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL5201239 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL5176690 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL5190813 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL1257065 | STILONIUM IODIDE | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL5200914 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL5174508 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL5197631 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL5176101 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL5176544 | — | Ki | = | 222.0 | nM | 6.65 |
| CHEMBL5182114 | — | Ki | = | 248.0 | nM | 6.61 |
| CHEMBL5193899 | — | Ki | = | 259.0 | nM | 6.59 |
| CHEMBL5170445 | — | Ki | = | 284.0 | nM | 6.55 |
| CHEMBL5191958 | — | Ki | = | 306.0 | nM | 6.51 |
| CHEMBL5193143 | — | Ki | = | 567.0 | nM | 6.25 |
| CHEMBL5171118 | — | Ki | = | 613.0 | nM | 6.21 |
| CHEMBL5181363 | — | Ki | = | 635.0 | nM | 6.20 |
| CHEMBL5182514 | — | Ki | = | 1123.0 | nM | 5.95 |
| CHEMBL5173112 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL5195695 | — | Ki | = | 2430.0 | nM | 5.61 |
| CHEMBL5186396 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL5184266 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL5176875 | — | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL5205894 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL5208202 | — | Ki | = | 50000.0 | nM | 4.30 |