Assay Detail
Binding
CHEMBL5137205
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-Tyr-SRIF 14 from human SST4 receptor expressed in membrane measured after 90 mins by gamma counting analysis
59
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: high affinity and selective somatostatin receptor-4 agonists for Alzheimer's disease treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 59 | 8.10 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5174969 | — | — | 1 | 9.30 |
| CHEMBL5183772 | — | — | 1 | 9.30 |
| CHEMBL5197201 | — | — | 1 | 9.30 |
| CHEMBL5185547 | — | — | 1 | 9.22 |
| CHEMBL5179456 | — | — | 1 | 9.15 |
| CHEMBL5175637 | — | — | 1 | 9.15 |
| CHEMBL5172814 | — | — | 1 | 9.15 |
| CHEMBL5193727 | — | — | 1 | 9.15 |
| CHEMBL5180543 | — | — | 1 | 9.10 |
| CHEMBL5177487 | — | — | 1 | 9.10 |
| CHEMBL5209180 | — | — | 1 | 9.05 |
| CHEMBL5177573 | — | — | 1 | 9.05 |
| CHEMBL5190457 | — | — | 1 | 9.00 |
| CHEMBL5171935 | — | — | 1 | 9.00 |
| CHEMBL5176083 | — | — | 1 | 8.96 |
| CHEMBL5190056 | — | — | 1 | 8.92 |
| CHEMBL5180551 | — | — | 1 | 8.85 |
| CHEMBL5173784 | — | — | 1 | 8.77 |
| CHEMBL5188841 | — | — | 1 | 8.77 |
| CHEMBL5208396 | — | — | 1 | 8.77 |
| CHEMBL5206148 | — | — | 1 | 8.74 |
| CHEMBL5193172 | — | — | 1 | 8.66 |
| CHEMBL5205998 | — | — | 1 | 8.59 |
| CHEMBL5195145 | — | — | 1 | 8.55 |
| CHEMBL5196971 | — | — | 1 | 8.52 |
| CHEMBL5178013 | — | — | 1 | 8.51 |
| CHEMBL5200786 | — | — | 1 | 8.49 |
| CHEMBL5198142 | — | — | 1 | 8.48 |
| CHEMBL5193686 | — | — | 1 | 8.29 |
| CHEMBL5205904 | — | — | 1 | 8.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5174969 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL5197201 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL5183772 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL5185547 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL5179456 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL5175637 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL5172814 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL5193727 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL5180543 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL5177487 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL5209180 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL5177573 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL5190457 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL5171935 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL5176083 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL5190056 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL5180551 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL5173784 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL5188841 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL5208396 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL5206148 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL5193172 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL5205998 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL5195145 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL5196971 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL5178013 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL5200786 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL5198142 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL5193686 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL5205904 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL5189042 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL5187631 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL5200112 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL5180752 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL5207543 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL5179321 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL5201594 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL5209165 | — | Ki | = | 12.4 | nM | 7.91 |
| CHEMBL5192791 | — | Ki | = | 14.9 | nM | 7.83 |
| CHEMBL5188361 | — | Ki | = | 16.2 | nM | 7.79 |
| CHEMBL5191532 | — | Ki | = | 21.5 | nM | 7.67 |
| CHEMBL5201540 | — | Ki | = | 30.3 | nM | 7.52 |
| CHEMBL5197218 | — | Ki | = | 36.6 | nM | 7.44 |
| CHEMBL5193951 | — | Ki | = | 37.5 | nM | 7.43 |
| CHEMBL5203972 | — | Ki | = | 39.5 | nM | 7.40 |
| CHEMBL5176020 | — | Ki | = | 40.4 | nM | 7.39 |
| CHEMBL5202717 | — | Ki | = | 51.7 | nM | 7.29 |
| CHEMBL5180116 | — | Ki | = | 57.1 | nM | 7.24 |
| CHEMBL5208764 | — | Ki | = | 58.8 | nM | 7.23 |
| CHEMBL5208037 | — | Ki | = | 80.8 | nM | 7.09 |