Compound Detail
CHEMBL5174969
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5174969 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RQGQSCHSKCCJEJ-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
448.9
MW (Da)
5.09
ALogP
4
HBA
2
HBD
75.2
PSA (Ų)
0.35
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 9.3
EC50 1 meas. best 9.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 4 CHEMBL1853 | Ki | 9.3 | 9.3 | 0.5 | 1 |
| Somatostatin receptor type 4 CHEMBL1853 | EC50 | 9.1 | 9.1 | 0.8 | 1 |
| Somatostatin receptor type 2 CHEMBL1804 | Ki | 5.76 | 5.76 | 1734.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 4 | Ki | = | 0.5 | nM | 9.3 | Displacement of [125I]-Tyr-SRIF 14 from human SST4 receptor expressed in membran... | 34458738 |
| Somatostatin receptor type 4 | EC50 | = | 0.8 | nM | 9.1 | Agonist activity at recombinant human SST4 receptor expressed in CHO-K1 cells as... | 34458738 |
| Somatostatin receptor type 2 | Ki | = | 1734.0 | nM | 5.76 | Displacement of [125I]-Tyr-SRIF 14 from human SST2A receptor expressed in membra... | 34458738 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34458738 | 10.1039/D1MD00044F | Somatostatin receptor type 4 | 2 |
| 34458738 | 10.1039/D1MD00044F | Somatostatin receptor type 2 | 1 |
Data from ChEMBL 36 via Core Engine