Assay Detail
Binding
CHEMBL5137679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of phosphorylation of eIF4E (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Eukaryotic translation initiation factor 4E (CHEMBL4848) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Update on the Development of MNK Inhibitors as Therapeutic Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.73 | 8.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5183975 | — | — | 1 | 8.50 |
| CHEMBL5203720 | — | — | 1 | 8.10 |
| CHEMBL5181488 | — | — | 1 | 8.10 |
| CHEMBL5206647 | — | — | 1 | 7.80 |
| CHEMBL5195407 | — | — | 1 | 7.60 |
| CHEMBL5171562 | — | — | 1 | 7.50 |
| CHEMBL5180948 | — | — | 1 | 7.50 |
| CHEMBL5205835 | — | — | 1 | 7.40 |
| CHEMBL5197975 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5183975 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL5203720 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL5181488 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL5206647 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL5195407 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL5171562 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL5180948 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL5205835 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5197975 | — | IC50 | = | 79.43 | nM | 7.10 |