Compound Detail
CHEMBL5183975
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Basic Information
| ChEMBL ID | CHEMBL5183975 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NQKUBPWGXDRNCR-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
422.6
MW (Da)
3.25
ALogP
7
HBA
2
HBD
83.0
PSA (Ų)
0.67
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MAP kinase-interacting serine/threonine-protein kinase 2 CHEMBL4204 | IC50 | 8.6 | 8.6 | 2.5 | 1 |
| MAP kinase-interacting serine/threonine-protein kinase 1 CHEMBL4718 | IC50 | 8.5 | 8.5 | 3.2 | 1 |
| Eukaryotic translation initiation factor 4E CHEMBL4848 | IC50 | 8.5 | 8.5 | 3.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MAP kinase-interacting serine/threonine-protein kinase 2 | IC50 | = | 2.512 | nM | 8.6 | Inhibition of Mnk2 (unknown origin) | 34533957 |
| MAP kinase-interacting serine/threonine-protein kinase 1 | IC50 | = | 3.162 | nM | 8.5 | Inhibition of Mnk1 (unknown origin) | 34533957 |
| Eukaryotic translation initiation factor 4E | IC50 | = | 3.162 | nM | 8.5 | Inhibition of phosphorylation of eIF4E (unknown origin) | 34533957 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34533957 | 10.1021/acs.jmedchem.1c00368 | MAP kinase-interacting serine/threonine-protein kinase 2 | 1 |
| 34533957 | 10.1021/acs.jmedchem.1c00368 | MAP kinase-interacting serine/threonine-protein kinase 1 | 1 |
| 34533957 | 10.1021/acs.jmedchem.1c00368 | Eukaryotic translation initiation factor 4E | 1 |
Data from ChEMBL 36 via Core Engine