Assay Detail
Binding
CHEMBL5137639
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mnk1 (unknown origin)
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
MAP kinase-interacting serine/threonine-protein kinase 1 (CHEMBL4718) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Update on the Development of MNK Inhibitors as Therapeutic Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.59 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4100554 | — | — | 1 | 8.72 |
| CHEMBL4073443 | TOMIVOSERTIB | 2.0 | 1 | 8.62 |
| CHEMBL5181488 | — | — | 1 | 8.60 |
| CHEMBL5180948 | — | — | 1 | 8.50 |
| CHEMBL5183975 | — | — | 1 | 8.50 |
| CHEMBL5196282 | — | — | 1 | 8.40 |
| CHEMBL5203720 | — | — | 1 | 8.30 |
| CHEMBL5204789 | — | — | 1 | 8.30 |
| CHEMBL5176495 | — | — | 1 | 8.22 |
| CHEMBL5206647 | — | — | 1 | 8.20 |
| CHEMBL5171562 | — | — | 1 | 8.00 |
| CHEMBL5196084 | — | — | 1 | 7.90 |
| CHEMBL4764756 | — | — | 1 | 7.75 |
| CHEMBL5183411 | — | — | 1 | 7.40 |
| CHEMBL5203734 | — | — | 1 | 7.40 |
| CHEMBL5197975 | — | — | 1 | 7.30 |
| CHEMBL5186068 | — | — | 1 | 7.30 |
| CHEMBL5195407 | — | — | 1 | 7.30 |
| CHEMBL5205835 | — | — | 1 | 7.30 |
| CHEMBL5195560 | — | — | 1 | 7.30 |
| CHEMBL4071021 | — | — | 1 | 7.22 |
| CHEMBL1241463 | — | — | 1 | 7.22 |
| CHEMBL5187414 | — | — | 1 | 7.20 |
| CHEMBL5184155 | — | — | 1 | 6.90 |
| CHEMBL5175341 | — | — | 1 | 6.80 |
| CHEMBL4065855 | — | — | 1 | 5.52 |
| CHEMBL5183800 | — | — | 1 | 4.75 |
| CHEMBL5206228 | — | — | 1 | - |
| CHEMBL5204310 | — | — | 1 | - |
| CHEMBL5183740 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4100554 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4073443 | TOMIVOSERTIB | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5181488 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL5180948 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL5183975 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL5196282 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5203720 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL5204789 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5176495 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5206647 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL5171562 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5196084 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL4764756 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5183411 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5203734 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5197975 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL5186068 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL5195407 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL5205835 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL5195560 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL4071021 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1241463 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5187414 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL5184155 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL5175341 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4065855 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5183800 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5206228 | — | IC50 | = | 45000.0 | nM | - |
| CHEMBL5204310 | — | IC50 | = | 80000.0 | nM | - |
| CHEMBL5183740 | — | IC50 | = | 329000.0 | nM | - |
| CHEMBL5199976 | — | IC50 | = | 104000.0 | nM | - |