Assay Detail
Binding
CHEMBL5137733
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of human recombinant full length His-tagged PKM2 (Asp354, Lys311, Glu397, Gly315 residues)
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.23 | 7.42 |
| EC90 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1089334 | — | — | 2 | 7.42 |
| CHEMBL1085588 | — | — | 2 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1089334 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1085588 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL1089334 | — | EC90 | = | 680.0 | nM | - |
| CHEMBL1085588 | — | EC90 | = | 470.0 | nM | - |