Assay Detail
Binding
CHEMBL5138019
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGF-BB-stimulated PDGFR autophosphorylation in mouse Swiss-3T3 cells treated for 2 hrs followed by PDGF-BB stimulation measured after 10 mins by immunoblot analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Swiss-3T3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
How the structural properties of the indole derivatives are important in kinase targeted drug design?: A case study on tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.43 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5204052 | — | — | 1 | 7.00 |
| CHEMBL7735 | — | — | 1 | 6.70 |
| CHEMBL7600 | — | — | 1 | 6.70 |
| CHEMBL7296 | — | — | 1 | 6.52 |
| CHEMBL7602 | — | — | 1 | 6.52 |
| CHEMBL6884 | — | — | 1 | 5.12 |
| CHEMBL414402 | — | — | 1 | - |
| CHEMBL7540 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5204052 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL7735 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL7600 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL7296 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL7602 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL6884 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL414402 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL7540 | — | IC50 | > | 30000.0 | nM | - |