Compound Detail
CHEMBL6884
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Basic Information
| ChEMBL ID | CHEMBL6884 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PWYJJIJHWOOEFN-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
274.3
MW (Da)
4.19
ALogP
1
HBA
2
HBD
48.6
PSA (Ų)
0.53
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor CHEMBL2095189 | IC50 | 5.12 | 5.12 | 7500.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.12 | 5.12 | 7500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor | IC50 | = | 7500.0 | nM | 5.12 | Antitumor activity measured by the inhibition of platelet-derived growth factor ... | 11855980 |
| Unchecked | IC50 | = | 7500.0 | nM | 5.12 | Inhibition of PDGF-BB-stimulated PDGFR autophosphorylation in mouse Swiss-3T3 ce... | 34864496 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11855980 | 10.1021/jm010988n | Platelet-derived growth factor receptor | 1 |
| 34864496 | 10.1016/j.bmc.2021.116534 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine