Assay Detail
Functional
CHEMBL5138139
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of mitotic arrest in human multiple myeloma cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Multiple myeloma cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A review on the treatment of multiple myeloma with small molecular agents in the past five years.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.18 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2347655 | FILANESIB | 2.0 | 1 | 8.21 |
| CHEMBL18442 | PLERIXAFOR | 4.0 | 1 | 7.57 |
| CHEMBL471728 | — | — | 1 | 5.30 |
| CHEMBL1454910 | NITROXOLINE | 4.0 | 1 | 5.28 |
| CHEMBL4789047 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2347655 | FILANESIB | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL18442 | PLERIXAFOR | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL471728 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1454910 | NITROXOLINE | IC50 | = | 5250.0 | nM | 5.28 |
| CHEMBL4789047 | — | IC50 | = | 28340.0 | nM | 4.55 |