Compound Detail
CHEMBL2347655
FILANESIB 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL2347655 |
| Name | FILANESIB |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | LLXISKGBWFTGEI-FQEVSTJZSA-N |
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
12
Publications
2
Known Names
5
Indications
1
Mechanisms
Molecular Properties
420.5
MW (Da)
3.88
ALogP
5
HBA
1
HBD
71.2
PSA (Ų)
0.72
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Kinesin-like protein 1 inhibitor | INHIBITOR | Kinesin-like protein KIF11 | ✓ | ✓ |
Indications
Multiple Myeloma Leukemia, Myeloid, Acute Leukemia, Plasma Cell Myelodysplastic Syndromes Neoplasms
Activity Summary
IC50 6 meas. best 9.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| HCT-116 CHEMBL394 | IC50 | 9.15 | 9.15 | 0.7 | 1 |
| Kinesin-like protein KIF11 CHEMBL4581 | IC50 | 8.22 | 8.1025 | 6.0 | 4 |
| Unchecked CHEMBL612545 | IC50 | 8.21 | 8.21 | 6.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| HCT-116 | IC50 | = | 0.7 | nM | 9.15 | Growth inhibition of human HCT116 cells after 72 hrs by MTS assay | 26396688 |
| Kinesin-like protein KIF11 | IC50 | = | 6.0 | nM | 8.22 | Inhibition of Eg5 (unknown origin) | 23434636 |
| Kinesin-like protein KIF11 | IC50 | = | 6.0 | nM | 8.22 | Inhibition EG5 (unknown origin) | 30055887 |
| Kinesin-like protein KIF11 | IC50 | = | 6.0 | nM | 8.22 | Inhibition of microtubule-stimulated Eg5 ATPase activity in human HL-60 cells af... | 30031975 |
| Unchecked | IC50 | = | 6.1 | nM | 8.21 | Induction of mitotic arrest in human multiple myeloma cells | 34974338 |
| Kinesin-like protein KIF11 | IC50 | = | 18.0 | nM | 7.75 | Inhibition of His-tagged KSP motor domain (1 to 369) (unknown origin) assessed a... | 26396688 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 4 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 23434636 | 10.1016/j.ejmech.2013.01.031 | Kinesin-like protein KIF11 | 1 |
| 26396688 | 10.1021/acsmedchemlett.5b00221 | Kinesin-like protein KIF11 | 1 |
| 26396688 | 10.1021/acsmedchemlett.5b00221 | HCT-116 | 1 |
| 30055887 | 10.1016/j.bmcl.2018.07.007 | Kinesin-like protein KIF11 | 1 |
| 30031975 | 10.1016/j.ejmech.2018.07.006 | Kinesin-like protein KIF11 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| 34974338 | 10.1016/j.ejmech.2021.114053 | Unchecked | 1 |
| - | 10.6019/EOS300108 | HepG2 | 1 |
Data from ChEMBL 36 via Core Engine