Assay Detail
Functional
CHEMBL3636400
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Growth inhibition of human HCT116 cells after 72 hrs by MTS assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Guided Design of Novel l-Cysteine Derivatives as Potent KSP Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.27 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2347655 | FILANESIB | 2.0 | 1 | 9.15 |
| CHEMBL228814 | ISPINESIB | 2.0 | 1 | 8.96 |
| CHEMBL3633535 | — | — | 1 | 8.59 |
| CHEMBL3633536 | — | — | 1 | 8.47 |
| CHEMBL3633537 | — | — | 1 | 8.41 |
| CHEMBL3633534 | — | — | 1 | 8.30 |
| CHEMBL3633365 | — | — | 1 | 7.96 |
| CHEMBL3633541 | — | — | 1 | 7.82 |
| CHEMBL3633526 | — | — | 1 | 7.60 |
| CHEMBL3633366 | — | — | 1 | 7.55 |
| CHEMBL3633527 | — | — | 1 | 7.39 |
| CHEMBL3633540 | — | — | 1 | 7.12 |
| CHEMBL3633531 | — | — | 1 | 6.91 |
| CHEMBL232133 | — | — | 1 | 6.67 |
| CHEMBL392369 | — | — | 1 | 6.67 |
| CHEMBL3633530 | — | — | 1 | 6.63 |
| CHEMBL3633529 | — | — | 1 | 6.54 |
| CHEMBL3633364 | — | — | 1 | 6.49 |
| CHEMBL3633538 | — | — | 1 | 6.40 |
| CHEMBL3633532 | — | — | 1 | 6.20 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 6.04 |
| CHEMBL3633528 | — | — | 1 | 5.89 |
| CHEMBL3633533 | — | — | 1 | 5.34 |
| CHEMBL3633539 | — | — | 1 | - |
| CHEMBL3632633 | — | — | 1 | - |
| CHEMBL3633542 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2347655 | FILANESIB | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL228814 | ISPINESIB | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3633535 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL3633536 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3633537 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL3633534 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3633365 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3633541 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3633526 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3633366 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3633527 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3633540 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL3633531 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL232133 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL392369 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL3633530 | — | IC50 | = | 234.0 | nM | 6.63 |
| CHEMBL3633529 | — | IC50 | = | 291.0 | nM | 6.54 |
| CHEMBL3633364 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL3633538 | — | IC50 | = | 395.0 | nM | 6.40 |
| CHEMBL3633532 | — | IC50 | = | 637.0 | nM | 6.20 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL3633528 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3633533 | — | IC50 | = | 4590.0 | nM | 5.34 |
| CHEMBL3633539 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3632633 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3633542 | — | IC50 | > | 10000.0 | nM | - |