Assay Detail

CHEMBL5138217

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of human recombinant TNKS1/TNKS2 (unknown origin) by chemiluminescent assay

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Tankyrase 1/2 (CHEMBL3038515) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Tankyrase 1/2 (CHEMBL3038515) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Tankyrase 1/2

CHEMBL3038515

Anchored from Assay target.

Protein identity Tankyrase 1/2

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	5 — Multiple protein complex / RNA
Curated By	Autocuration

Target

Tankyrase 1/2 (CHEMBL3038515) ↗

Type	PROTEIN FAMILY
Organism	Homo sapiens

Publication

Dual-target inhibitors of poly (ADP-ribose) polymerase-1 for cancer therapy: Advances, challenges, and opportunities.

Hu X, Zhang J, Zhang Y, Jiao F, Wang J, Chen H, Ouyang L, Wang Y.
Eur J Med Chem (2022) 230 : 114094 -114094
PubMed 34998039 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.30	7.30

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3644587	2X-121	2.0	1	7.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3644587	2X-121	IC50	=	50.0	nM	7.30