Assay Detail
Binding
CHEMBL5138235
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PRMT4 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-arginine methyltransferase CARM1 (CHEMBL5406) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Fascinating Transformation of SAM-Competitive Protein Methyltransferase Inhibitors from Nucleoside Analogues to Non-Nucleoside Analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.71 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5195877 | — | — | 1 | 7.05 |
| CHEMBL5197586 | — | — | 1 | 5.96 |
| CHEMBL5172325 | — | — | 1 | 5.82 |
| CHEMBL5189462 | — | — | 1 | 5.64 |
| CHEMBL5194544 | — | — | 1 | 5.06 |
| CHEMBL5179361 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5195877 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5197586 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5172325 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5189462 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5194544 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL5179361 | — | IC50 | = | 17700.0 | nM | 4.75 |