Assay Detail
Binding
CHEMBL5138249
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PRMT5 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 5 (CHEMBL1795116) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Fascinating Transformation of SAM-Competitive Protein Methyltransferase Inhibitors from Nucleoside Analogues to Non-Nucleoside Analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.13 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5203719 | — | — | 1 | 9.89 |
| CHEMBL5187591 | — | — | 1 | 9.40 |
| CHEMBL5180860 | — | — | 1 | 8.02 |
| CHEMBL5190643 | — | — | 1 | 5.22 |
| CHEMBL4092336 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5203719 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL5187591 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5180860 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL5190643 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4092336 | — | IC50 | = | 0.33 | nM | - |