Assay Detail
Functional
CHEMBL5138280
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Inhibition of lactate production in human MIA PaCa-2 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.43 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5201115 | — | — | 1 | 5.77 |
| CHEMBL5183539 | — | — | 1 | 5.70 |
| CHEMBL5181496 | — | — | 1 | 5.66 |
| CHEMBL5188480 | — | — | 1 | 5.44 |
| CHEMBL5194549 | — | — | 1 | 5.28 |
| CHEMBL5196929 | — | — | 1 | 5.14 |
| CHEMBL5202219 | — | — | 1 | 5.04 |
| CHEMBL5171701 | — | — | 1 | - |
| CHEMBL5196259 | — | — | 1 | - |
| CHEMBL5185237 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5201115 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5183539 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5181496 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5188480 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5194549 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5196929 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5202219 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL5171701 | — | IC50 | - | — | - | |
| CHEMBL5196259 | — | IC50 | - | — | - | |
| CHEMBL5185237 | — | IC50 | - | — | - |