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Compound Detail

CHEMBL5171701

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O=C1NC(c2cccc(NCCC3CC3)n2)(c2cccc(Nc3ccc(F)c(F)c3)n2)CC(O)=C1Sc1ccccc1Cl

Basic Information

ChEMBL ID CHEMBL5171701
Phase Preclinical
Structure Type MOL
InChI Key XJPQZHPKRRVQMS-UHFFFAOYSA-N
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

620.1
MW (Da)
7.69
ALogP
7
HBA
4
HBD
99.2
PSA (Ų)
0.14
QED
2
Ro5 Violations
10
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C32H28ClF2N5O2S
MW 620.12
Aromatic Rings 4
Heavy Atoms 43
NP-Likeness -1.11

Activity Summary

IC50 4 meas. best 7.89

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
L-lactate dehydrogenase A chain
CHEMBL4835
IC50 7.89 7.305 13.0 2
L-lactate dehydrogenase B chain
CHEMBL4940
IC50 6.77 6.26 170.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
35065235 10.1016/j.bmcl.2022.128576 L-lactate dehydrogenase A chain 2
35065235 10.1016/j.bmcl.2022.128576 L-lactate dehydrogenase B chain 2
35065235 10.1016/j.bmcl.2022.128576 Unchecked 1
35065235 10.1016/j.bmcl.2022.128576 No relevant target 1

Data from ChEMBL 36 via Core Engine