Assay Detail
Binding
CHEMBL5138491
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Inhibition of jack bean urease
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canavalia ensiformis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An overview on the synthetic urease inhibitors with structure-activity relationship and molecular docking.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.55 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5204803 | — | — | 1 | 7.24 |
| CHEMBL5193802 | — | — | 1 | 7.11 |
| CHEMBL5178598 | — | — | 1 | 6.96 |
| CHEMBL5182053 | — | — | 1 | 5.90 |
| CHEMBL5185374 | — | — | 1 | 5.70 |
| CHEMBL5178823 | — | — | 1 | 5.49 |
| CHEMBL5182165 | — | — | 1 | 5.37 |
| CHEMBL196 | ASCORBIC ACID | 4.0 | 1 | 5.07 |
| CHEMBL5197997 | — | — | 1 | 4.96 |
| CHEMBL5183641 | — | — | 1 | 4.95 |
| CHEMBL5183545 | — | — | 1 | 4.93 |
| CHEMBL1466 | DICUMAROL | 4.0 | 1 | 4.82 |
| CHEMBL260876 | THIOUREA | — | 1 | 4.68 |
| CHEMBL5170167 | — | — | 1 | 4.51 |
| CHEMBL5190120 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5204803 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5193802 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL5178598 | — | IC50 | = | 110.8 | nM | 6.96 |
| CHEMBL5182053 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL5185374 | — | IC50 | = | 1975.0 | nM | 5.70 |
| CHEMBL5178823 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL5182165 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL196 | ASCORBIC ACID | IC50 | = | 8590.0 | nM | 5.07 |
| CHEMBL5197997 | — | IC50 | = | 11010.0 | nM | 4.96 |
| CHEMBL5183641 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL5183545 | — | IC50 | = | 11730.0 | nM | 4.93 |
| CHEMBL1466 | DICUMAROL | IC50 | = | 15010.0 | nM | 4.82 |
| CHEMBL260876 | THIOUREA | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL5170167 | — | IC50 | = | 31100.0 | nM | 4.51 |
| CHEMBL5190120 | — | IC50 | = | 1.88 | ug.mL-1 | - |