Assay Detail
Binding
CHEMBL5138495
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of jack bean urease assessed as reduction on ammonia production using urea as substrate incubated for 15 mins by indophenol reagent based microplate reader assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canavalia ensiformis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An overview on the synthetic urease inhibitors with structure-activity relationship and molecular docking.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.93 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3600655 | — | — | 1 | 5.42 |
| CHEMBL4776100 | — | — | 1 | 5.16 |
| CHEMBL5198588 | — | — | 1 | 5.13 |
| CHEMBL5185783 | — | — | 1 | 4.90 |
| CHEMBL5177130 | — | — | 1 | 4.81 |
| CHEMBL5179293 | — | — | 1 | 4.66 |
| CHEMBL5204682 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3600655 | — | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL4776100 | — | IC50 | = | 6880.0 | nM | 5.16 |
| CHEMBL5198588 | — | IC50 | = | 7370.0 | nM | 5.13 |
| CHEMBL5185783 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL5177130 | — | IC50 | = | 15640.0 | nM | 4.81 |
| CHEMBL5179293 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL5204682 | — | IC50 | = | 36000.0 | nM | 4.44 |