Assay Detail
Binding
CHEMBL5138507
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR (unknown origin)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Dual Inhibitors Targeting Epidermal Growth Factor Receptor in Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.70 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4099329 | — | — | 1 | 8.96 |
| CHEMBL31965 | CANERTINIB | 3.0 | 1 | 8.82 |
| CHEMBL587723 | AEE-788 | 2.0 | 1 | 8.70 |
| CHEMBL4116552 | — | — | 1 | 8.64 |
| CHEMBL4117373 | — | — | 1 | 8.31 |
| CHEMBL5201054 | — | — | 1 | 7.99 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 7.97 |
| CHEMBL4088718 | — | — | 1 | 7.76 |
| CHEMBL1645462 | AC-480 | 1.0 | 1 | 7.70 |
| CHEMBL4065300 | — | — | 1 | 7.22 |
| CHEMBL5194719 | — | — | 1 | 7.05 |
| CHEMBL5203711 | — | — | 1 | 6.92 |
| CHEMBL4286374 | — | — | 1 | 6.92 |
| CHEMBL4073912 | — | — | 1 | 6.86 |
| CHEMBL4294264 | — | — | 1 | 5.71 |
| CHEMBL4569885 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4099329 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL31965 | CANERTINIB | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL587723 | AEE-788 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4116552 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4117373 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL5201054 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL554 | LAPATINIB | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL4088718 | — | IC50 | = | 17.2 | nM | 7.76 |
| CHEMBL1645462 | AC-480 | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4065300 | — | IC50 | = | 60.1 | nM | 7.22 |
| CHEMBL5194719 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5203711 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4286374 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4073912 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL4294264 | — | IC50 | = | 1935.0 | nM | 5.71 |
| CHEMBL4569885 | — | IC50 | = | 30000.0 | nM | - |