Assay Detail
Functional
CHEMBL5138682
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticancer activity against human HCT-15 cells assessed as reduction in cell viability for 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.62 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3327388 | — | — | 1 | 6.22 |
| CHEMBL28457 | ALKANNIN | — | 1 | 5.96 |
| CHEMBL5199683 | — | — | 1 | 5.90 |
| CHEMBL5189545 | — | — | 1 | 5.54 |
| CHEMBL5208936 | — | — | 1 | 5.18 |
| CHEMBL5174035 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3327388 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL28457 | ALKANNIN | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL5199683 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL5189545 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL5208936 | — | IC50 | = | 6590.0 | nM | 5.18 |
| CHEMBL5174035 | — | IC50 | = | 12500.0 | nM | 4.90 |