Assay Detail
Binding
CHEMBL5138963
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to full length recombinant PRMT4 (unknown origin) assessed as dissociation constant by surface plasmon resonance
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-arginine methyltransferase CARM1 (CHEMBL5406) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 6.56 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5172334 | — | — | 1 | 8.02 |
| CHEMBL5191769 | — | — | 1 | 7.29 |
| CHEMBL5173678 | — | — | 1 | 7.12 |
| CHEMBL5202088 | — | — | 1 | 6.60 |
| CHEMBL5206272 | — | — | 1 | 6.45 |
| CHEMBL5186617 | — | — | 1 | 6.22 |
| CHEMBL5199380 | — | — | 1 | 6.18 |
| CHEMBL5170047 | — | — | 1 | 5.64 |
| CHEMBL5180108 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5172334 | — | Kd | = | 9.6 | nM | 8.02 |
| CHEMBL5191769 | — | Kd | = | 51.7 | nM | 7.29 |
| CHEMBL5173678 | — | Kd | = | 75.9 | nM | 7.12 |
| CHEMBL5202088 | — | Kd | = | 252.0 | nM | 6.60 |
| CHEMBL5206272 | — | Kd | = | 359.2 | nM | 6.45 |
| CHEMBL5186617 | — | Kd | = | 603.4 | nM | 6.22 |
| CHEMBL5199380 | — | Kd | = | 663.4 | nM | 6.18 |
| CHEMBL5170047 | — | Kd | = | 2300.0 | nM | 5.64 |
| CHEMBL5180108 | — | Kd | = | 2800.0 | nM | 5.55 |