Assay Detail
Functional
CHEMBL5139210
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Antiviral activity against Enterovirus A71 BrCr harboring VP1_P246S mutant infected in RD cells assessed as protection against virus induced cytopatheic effect measured after 5 days by MTS assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Enterovirus A71 |
| Cell Type | RD |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Organotropic dendrons with high potency as HIV-1, HIV-2 and EV-A71 cell entry inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.09 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5179843 | — | — | 1 | 7.22 |
| CHEMBL4451994 | — | — | 1 | 5.72 |
| CHEMBL5188311 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5179843 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4451994 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5188311 | — | EC50 | = | 4700.0 | nM | 5.33 |