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Assay Detail

CHEMBL5139399

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human SK-N-SH cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-N-SH
Confidence 1 — Organism
Curated By Autocuration

Target

SK-N-SH (CHEMBL614924)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of novel coumarin-indole derivatives as tubulin polymerization inhibitors with potent anti-gastric cancer activities.
Song J, Guan YF, Liu WB, Song CH, Tian XY, Zhu T, Fu XJ, Qi YQ, Zhang SY.
Eur J Med Chem (2022) 238 : 114467 -114467
PubMed 35605363 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.22 7.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5176373 1 7.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5176373 IC50 = 59.57 nM 7.22