Assay Detail
Functional
CHEMBL5139773
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Antiproliferative activity against human THLE-2 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THLE-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of quinazoline derivatives CZw-124 as a pan-TRK inhibitor with potent anticancer effects in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.35 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5206613 | — | — | 1 | 5.89 |
| CHEMBL5175892 | — | — | 1 | 5.60 |
| CHEMBL5174615 | — | — | 1 | 5.54 |
| CHEMBL5184749 | — | — | 1 | 4.36 |
| CHEMBL4856292 | — | — | 1 | - |
| CHEMBL5193032 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5206613 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5175892 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5174615 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5184749 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL4856292 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5193032 | — | IC50 | > | 100000.0 | nM | - |