Assay Detail
Functional
CHEMBL5139776
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Antiproliferative activity against mouse BaF3 cells harboring TRKA F589L mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of quinazoline derivatives CZw-124 as a pan-TRK inhibitor with potent anticancer effects in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.57 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297627 | SELITRECTINIB | 2.0 | 1 | 8.09 |
| CHEMBL5175892 | — | — | 1 | 7.80 |
| CHEMBL5206613 | — | — | 1 | 7.70 |
| CHEMBL457614 | — | — | 1 | 7.70 |
| CHEMBL4856292 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297627 | SELITRECTINIB | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL5175892 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5206613 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL457614 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4856292 | — | IC50 | = | 260.0 | nM | 6.58 |