Assay Detail
Binding
CHEMBL5139891
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS-CoV-2 papain-like protease using ISG15-Rh as substrate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.33 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL486027 | METHYL PROTOCATECHUATE | — | 1 | 5.42 |
| CHEMBL14193 | 4-HYDROXYBENZALDEHYDE | — | 1 | 5.40 |
| CHEMBL53566 | TYROSOL | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL486027 | METHYL PROTOCATECHUATE | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL14193 | 4-HYDROXYBENZALDEHYDE | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL53566 | TYROSOL | IC50 | = | 6680.0 | nM | 5.17 |