Assay Detail
Functional
CHEMBL5139984
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Antiviral activity against HSV-1 infected in African green monkey Vero cells assessed as inhibition of viral replication incubated for 1 hr followed by washing with PBS and subsequent treatment with compound for 24 hrs by plaque reduction assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.76 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4454397 | — | — | 1 | 7.22 |
| CHEMBL5205701 | — | — | 1 | 6.82 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 6.80 |
| CHEMBL5187428 | — | — | 1 | 6.80 |
| CHEMBL5190021 | — | — | 1 | 6.68 |
| CHEMBL5180128 | — | — | 1 | 6.62 |
| CHEMBL1413 | CICLOPIROX | 4.0 | 1 | 6.57 |
| CHEMBL5185946 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4454397 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5205701 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5187428 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5190021 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5180128 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1413 | CICLOPIROX | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5185946 | — | EC50 | = | 290.0 | nM | 6.54 |