Assay Detail
Functional
CHEMBL5140364
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against drug-resistant HIV-1 L100I mutant infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by MTT assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Expansion of the S-CN-DABO scaffold to exploit the impact on inhibitory activities against the non-nucleoside HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 43 | 5.41 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.08 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 7.94 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.43 |
| CHEMBL5180920 | — | — | 1 | 6.40 |
| CHEMBL5187988 | — | — | 1 | 5.99 |
| CHEMBL5174000 | — | — | 1 | 5.97 |
| CHEMBL5205629 | — | — | 1 | 5.75 |
| CHEMBL5190637 | — | — | 1 | 5.70 |
| CHEMBL5173017 | — | — | 1 | 5.69 |
| CHEMBL5188407 | — | — | 1 | 5.64 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.59 |
| CHEMBL5195817 | — | — | 1 | 5.56 |
| CHEMBL5183294 | — | — | 1 | 5.49 |
| CHEMBL5170094 | — | — | 1 | 5.47 |
| CHEMBL5186337 | — | — | 1 | 5.47 |
| CHEMBL5197703 | — | — | 1 | 5.45 |
| CHEMBL5174481 | — | — | 1 | 5.41 |
| CHEMBL5191672 | — | — | 1 | 5.26 |
| CHEMBL5204500 | — | — | 1 | 5.23 |
| CHEMBL5203279 | — | — | 1 | 5.13 |
| CHEMBL5199869 | — | — | 1 | 5.01 |
| CHEMBL5186285 | — | — | 1 | 5.00 |
| CHEMBL374286 | — | — | 1 | 4.99 |
| CHEMBL5201823 | — | — | 1 | 4.95 |
| CHEMBL5202355 | — | — | 1 | 4.92 |
| CHEMBL5190141 | — | — | 1 | 4.87 |
| CHEMBL5201738 | — | — | 1 | 4.73 |
| CHEMBL5190744 | — | — | 1 | 4.72 |
| CHEMBL5175287 | — | — | 1 | 4.62 |
| CHEMBL5188648 | — | — | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 8.4 | nM | 8.08 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 11.5 | nM | 7.94 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 37.1 | nM | 7.43 |
| CHEMBL5180920 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5187988 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL5174000 | — | EC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL5205629 | — | EC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL5190637 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5173017 | — | EC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL5188407 | — | EC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 2565.8 | nM | 5.59 |
| CHEMBL5195817 | — | EC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL5183294 | — | EC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL5170094 | — | EC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL5186337 | — | EC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL5197703 | — | EC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL5174481 | — | EC50 | = | 3940.0 | nM | 5.41 |
| CHEMBL5191672 | — | EC50 | = | 5510.0 | nM | 5.26 |
| CHEMBL5204500 | — | EC50 | = | 5920.0 | nM | 5.23 |
| CHEMBL5203279 | — | EC50 | = | 7370.0 | nM | 5.13 |
| CHEMBL5199869 | — | EC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL5186285 | — | EC50 | = | 10030.0 | nM | 5.00 |
| CHEMBL374286 | — | EC50 | = | 10350.0 | nM | 4.99 |
| CHEMBL5201823 | — | EC50 | = | 11220.0 | nM | 4.95 |
| CHEMBL5202355 | — | EC50 | = | 12140.0 | nM | 4.92 |
| CHEMBL5190141 | — | EC50 | = | 13530.0 | nM | 4.87 |
| CHEMBL5201738 | — | EC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL5190744 | — | EC50 | = | 19050.0 | nM | 4.72 |
| CHEMBL5175287 | — | EC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL5188648 | — | EC50 | = | 32290.0 | nM | 4.49 |
| CHEMBL5181568 | — | EC50 | = | 45930.0 | nM | 4.34 |
| CHEMBL5171760 | — | EC50 | = | 47900.0 | nM | 4.32 |
| CHEMBL5171797 | — | EC50 | = | 56960.0 | nM | 4.24 |
| CHEMBL5174260 | — | EC50 | = | 63540.0 | nM | 4.20 |
| CHEMBL5192943 | — | EC50 | > | 12860.0 | nM | - |
| CHEMBL5169873 | — | EC50 | > | 277520.0 | nM | - |
| CHEMBL5183658 | — | EC50 | > | 23140.0 | nM | - |
| CHEMBL5194378 | — | EC50 | - | — | - | |
| CHEMBL5176289 | — | EC50 | > | 13170.0 | nM | - |
| CHEMBL5193413 | — | EC50 | > | 14380.0 | nM | - |
| CHEMBL5180025 | — | EC50 | > | 10310.0 | nM | - |
| CHEMBL5208866 | — | EC50 | > | 39790.0 | nM | - |
| CHEMBL5170052 | — | EC50 | > | 68100.0 | nM | - |