Assay Detail
Functional
CHEMBL5140366
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against drug-resistant HIV-1 Y181C mutant infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by MTT assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Expansion of the S-CN-DABO scaffold to exploit the impact on inhibitory activities against the non-nucleoside HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 43 | 5.44 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.15 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 7.79 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.62 |
| CHEMBL5187988 | — | — | 1 | 6.12 |
| CHEMBL5174000 | — | — | 1 | 5.85 |
| CHEMBL5180920 | — | — | 1 | 5.72 |
| CHEMBL5205629 | — | — | 1 | 5.46 |
| CHEMBL5197703 | — | — | 1 | 5.41 |
| CHEMBL5186337 | — | — | 1 | 5.40 |
| CHEMBL5188407 | — | — | 1 | 5.39 |
| CHEMBL5173017 | — | — | 1 | 5.36 |
| CHEMBL5174481 | — | — | 1 | 5.28 |
| CHEMBL5190637 | — | — | 1 | 5.28 |
| CHEMBL5183294 | — | — | 1 | 5.26 |
| CHEMBL5195817 | — | — | 1 | 5.24 |
| CHEMBL5203279 | — | — | 1 | 5.19 |
| CHEMBL5190141 | — | — | 1 | 5.16 |
| CHEMBL5201823 | — | — | 1 | 5.14 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.11 |
| CHEMBL5201738 | — | — | 1 | 5.06 |
| CHEMBL374286 | — | — | 1 | 5.04 |
| CHEMBL5204500 | — | — | 1 | 5.00 |
| CHEMBL5202355 | — | — | 1 | 5.00 |
| CHEMBL5191672 | — | — | 1 | 4.99 |
| CHEMBL5176289 | — | — | 1 | 4.94 |
| CHEMBL5190744 | — | — | 1 | 4.90 |
| CHEMBL5188648 | — | — | 1 | 4.38 |
| CHEMBL5186285 | — | — | 1 | 4.29 |
| CHEMBL5181568 | — | — | 1 | 4.29 |
| CHEMBL5174260 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 16.2 | nM | 7.79 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 24.2 | nM | 7.62 |
| CHEMBL5187988 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5174000 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5180920 | — | EC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL5205629 | — | EC50 | = | 3470.0 | nM | 5.46 |
| CHEMBL5197703 | — | EC50 | = | 3920.0 | nM | 5.41 |
| CHEMBL5186337 | — | EC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL5188407 | — | EC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL5173017 | — | EC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL5190637 | — | EC50 | = | 5280.0 | nM | 5.28 |
| CHEMBL5174481 | — | EC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL5183294 | — | EC50 | = | 5520.0 | nM | 5.26 |
| CHEMBL5195817 | — | EC50 | = | 5820.0 | nM | 5.24 |
| CHEMBL5203279 | — | EC50 | = | 6430.0 | nM | 5.19 |
| CHEMBL5190141 | — | EC50 | = | 6890.0 | nM | 5.16 |
| CHEMBL5201823 | — | EC50 | = | 7270.0 | nM | 5.14 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 7711.6 | nM | 5.11 |
| CHEMBL5201738 | — | EC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL374286 | — | EC50 | = | 9210.0 | nM | 5.04 |
| CHEMBL5204500 | — | EC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL5202355 | — | EC50 | = | 9980.0 | nM | 5.00 |
| CHEMBL5191672 | — | EC50 | = | 10160.0 | nM | 4.99 |
| CHEMBL5176289 | — | EC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL5190744 | — | EC50 | = | 12540.0 | nM | 4.90 |
| CHEMBL5188648 | — | EC50 | = | 41300.0 | nM | 4.38 |
| CHEMBL5186285 | — | EC50 | = | 50700.0 | nM | 4.29 |
| CHEMBL5181568 | — | EC50 | = | 51200.0 | nM | 4.29 |
| CHEMBL5194378 | — | EC50 | - | — | - | |
| CHEMBL5192943 | — | EC50 | > | 12860.0 | nM | - |
| CHEMBL5170052 | — | EC50 | > | 68100.0 | nM | - |
| CHEMBL5199869 | — | EC50 | > | 37100.0 | nM | - |
| CHEMBL5180025 | — | EC50 | > | 47080.0 | nM | - |
| CHEMBL5170094 | — | EC50 | > | 41120.0 | nM | - |
| CHEMBL5183658 | — | EC50 | > | 23140.0 | nM | - |
| CHEMBL5169873 | — | EC50 | = | 185600.0 | nM | - |
| CHEMBL5208866 | — | EC50 | > | 39790.0 | nM | - |
| CHEMBL5171797 | — | EC50 | > | 164080.0 | nM | - |
| CHEMBL5171760 | — | EC50 | > | 362770.0 | nM | - |
| CHEMBL5175287 | — | EC50 | > | 60870.0 | nM | - |
| CHEMBL5193413 | — | EC50 | > | 70220.0 | nM | - |
| CHEMBL5174260 | — | EC50 | > | 113150.0 | nM | - |