Assay Detail
Binding
CHEMBL5140630
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Inhibition of microRNA in human HeLa cells transfected with pCI-neo-luciferase-miR-21 plasmid assessed as change in luciferase signal incubated for 24 hrs by luciferase reporter assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.43 | 5.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170759 | — | — | 1 | 5.86 |
| CHEMBL5178502 | — | — | 1 | 5.73 |
| CHEMBL5180444 | — | — | 1 | 5.52 |
| CHEMBL5175086 | — | — | 1 | 5.22 |
| CHEMBL5179203 | — | — | 1 | 5.13 |
| CHEMBL5189546 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170759 | — | EC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL5178502 | — | EC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL5180444 | — | EC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL5175086 | — | EC50 | = | 5980.0 | nM | 5.22 |
| CHEMBL5179203 | — | EC50 | = | 7340.0 | nM | 5.13 |
| CHEMBL5189546 | — | EC50 | = | 7440.0 | nM | 5.13 |