Compound Detail
CHEMBL5178502
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Basic Information
| ChEMBL ID | CHEMBL5178502 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NVVGQYITPUWMOH-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
307.4
MW (Da)
4.49
ALogP
4
HBA
0
HBD
52.3
PSA (Ų)
0.67
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.73
Kd 1 meas. best 6.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RISC-loading complex subunit TARBP2 CHEMBL2098 | Kd | 6.9 | 6.9 | 126.1 | 1 |
| Unchecked CHEMBL612545 | EC50 | 5.73 | 5.73 | 1850.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RISC-loading complex subunit TARBP2 | Kd | = | 126.1 | nM | 6.9 | Binding affinity to human recombinant TRBP by SPR assay | 35695407 |
| Unchecked | EC50 | = | 1850.0 | nM | 5.73 | Inhibition of microRNA in human HeLa cells transfected with pCI-neo-luciferase-m... | 35695407 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35695407 | 10.1021/acs.jmedchem.2c00189 | Unchecked | 2 |
| 35695407 | 10.1021/acs.jmedchem.2c00189 | SK-HEP1 | 2 |
| 35695407 | 10.1021/acs.jmedchem.2c00189 | RISC-loading complex subunit TARBP2 | 1 |
Data from ChEMBL 36 via Core Engine