Use UniProt Q15633 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL2098 Target Snapshot
RISC-loading complex subunit TARBP2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q15633. Use UniProt Q15633 as the stable identity anchor, then attach disease evidence before program review.
RISC-loading complex subunit TARBP2
Review this target as RISC-loading complex subunit TARBP2, mapped to UniProt Q15633. Sequence length is 366 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats RISC-loading complex subunit TARBP2 as ChEMBL target CHEMBL2098, mapped to UniProt Q15633. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether RISC-loading complex subunit TARBP2 is the right protein anchor across sources, using UniProt Q15633 as the stable mapping.
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Open Review-ready CardBasic Information
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| Preferred Name | RISC-loading complex subunit TARBP2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q15633 |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | RISC-loading complex subunit TARBP2 |
| UniProt Accession | Q15633 |
| Component Type | Protein |
| Sequence Length | 366 aa |
RISC-loading complex subunit TARBP2
How to read this target
Review this target as RISC-loading complex subunit TARBP2, mapped to UniProt Q15633. Sequence length is 366 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5170759 | 7.98 | Kd | 10.42 | Preclinical |
| CHEMBL5180444 | 7.72 | Kd | 19.19 | Preclinical |
| CHEMBL826 | 7.03 | Kd | 94.0 | Approved |
| CHEMBL5178502 | 6.9 | Kd | 126.1 | Preclinical |
| CHEMBL5175086 | 6.63 | Kd | 235.4 | Preclinical |
| CHEMBL5201452 | 6.17 | Kd | 679.8 | Preclinical |
| CHEMBL5189546 | 5.82 | Kd | 1502.0 | Preclinical |
| CHEMBL5179203 | 5.74 | Kd | 1822.0 | Preclinical |
| CHEMBL463499 | 5.17 | Kd | 6790.0 | Preclinical |
| CHEMBL5077274 | 5.17 | Kd | 6790.0 | Preclinical |
pChEMBL Value Distribution
Approved Drugs
Assay Landscape
Binding — 7 assays, 14 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 4 | 13 | 5.8 |
| cell-based format | 2 | 0 | — |
| assay format | 1 | 1 | 7.0 |