Assay Detail
Binding
CHEMBL5140636
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Inhibition of HPK1 (unknown origin) in presence of ATP
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase kinase 1 (CHEMBL5749) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Hematopoietic Progenitor Kinase 1 in Tumor Immunology: A Medicinal Chemistry Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.38 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5205694 | — | — | 1 | 10.30 |
| CHEMBL5191529 | — | — | 1 | 8.30 |
| CHEMBL5196866 | — | — | 1 | 8.30 |
| CHEMBL5199922 | — | — | 1 | 8.00 |
| CHEMBL5184909 | — | — | 1 | 7.00 |
| CHEMBL5173512 | — | — | 1 | - |
| CHEMBL5200242 | — | — | 1 | - |
| CHEMBL4754657 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5205694 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL5191529 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5196866 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5199922 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5184909 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5173512 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL5200242 | — | IC50 | <= | 5.0 | nM | - |
| CHEMBL4754657 | — | IC50 | <= | 5.0 | nM | - |