Compound Detail
CHEMBL5191529
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Basic Information
| ChEMBL ID | CHEMBL5191529 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZXCLJAYBOJECIX-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
505.5
MW (Da)
5.23
ALogP
7
HBA
2
HBD
79.4
PSA (Ų)
0.44
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase kinase kinase kinase 1 CHEMBL5749 | IC50 | 8.3 | 8.21 | 5.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase kinase kinase kinase 1 | IC50 | = | 5.0 | nM | 8.3 | Inhibition of HPK1 (unknown origin) in presence of ATP | 35696642 |
| Mitogen-activated protein kinase kinase kinase kinase 1 | IC50 | = | 7.5 | nM | 8.12 | Enzymatic Activity Assay: The enzymatic activity of Wild Type HPK1 (MAP4K1) Kina... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35696642 | 10.1021/acs.jmedchem.2c00172 | Mitogen-activated protein kinase kinase kinase kinase 1 | 1 |
Data from ChEMBL 36 via Core Engine