Assay Detail
Functional
CHEMBL5140670
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Antiproliferative activity against human H1975 cells assessed as cell viability after 72 hrs by MTT assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel osimertinib derivatives as reversible EGFR kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 5.46 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 7.14 |
| CHEMBL5199169 | — | — | 1 | 6.19 |
| CHEMBL5191292 | — | — | 1 | 6.00 |
| CHEMBL5189183 | — | — | 1 | 5.96 |
| CHEMBL5174047 | — | — | 1 | 5.94 |
| CHEMBL5188618 | — | — | 1 | 5.91 |
| CHEMBL5177394 | — | — | 1 | 5.90 |
| CHEMBL5174257 | — | — | 1 | 5.83 |
| CHEMBL5201846 | — | — | 1 | 5.81 |
| CHEMBL5203821 | — | — | 1 | 5.76 |
| CHEMBL5173534 | — | — | 1 | 5.74 |
| CHEMBL5197356 | — | — | 1 | 5.71 |
| CHEMBL5209075 | — | — | 1 | 5.69 |
| CHEMBL5198685 | — | — | 1 | 5.67 |
| CHEMBL5206298 | — | — | 1 | 5.67 |
| CHEMBL5173855 | — | — | 1 | 5.54 |
| CHEMBL5187781 | — | — | 1 | 5.51 |
| CHEMBL5196254 | — | — | 1 | 5.48 |
| CHEMBL5198181 | — | — | 1 | 5.44 |
| CHEMBL5177772 | — | — | 1 | 5.38 |
| CHEMBL5185772 | — | — | 1 | 5.38 |
| CHEMBL5175316 | — | — | 1 | 5.37 |
| CHEMBL5171169 | — | — | 1 | 5.36 |
| CHEMBL5190854 | — | — | 1 | 5.36 |
| CHEMBL5190280 | — | — | 1 | 5.27 |
| CHEMBL5207791 | — | — | 1 | 5.23 |
| CHEMBL5174232 | — | — | 1 | 5.16 |
| CHEMBL5201897 | — | — | 1 | 5.04 |
| CHEMBL5203877 | — | — | 1 | 4.99 |
| CHEMBL5189039 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL5199169 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL5191292 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL5189183 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL5174047 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL5188618 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL5177394 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL5174257 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL5201846 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL5203821 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL5173534 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL5197356 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL5209075 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL5198685 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL5206298 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL5173855 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL5187781 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL5196254 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL5198181 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL5185772 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5177772 | — | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL5175316 | — | IC50 | = | 4230.0 | nM | 5.37 |
| CHEMBL5171169 | — | IC50 | = | 4370.0 | nM | 5.36 |
| CHEMBL5190854 | — | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL5190280 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5207791 | — | IC50 | = | 5920.0 | nM | 5.23 |
| CHEMBL5174232 | — | IC50 | = | 6860.0 | nM | 5.16 |
| CHEMBL5201897 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL5203877 | — | IC50 | = | 10350.0 | nM | 4.99 |
| CHEMBL5189039 | — | IC50 | = | 10570.0 | nM | 4.98 |
| CHEMBL5180848 | — | IC50 | = | 11970.0 | nM | 4.92 |
| CHEMBL5179050 | — | IC50 | = | 12090.0 | nM | 4.92 |
| CHEMBL5187725 | — | IC50 | = | 13490.0 | nM | 4.87 |
| CHEMBL5181628 | — | IC50 | = | 16340.0 | nM | 4.79 |
| CHEMBL5207538 | — | IC50 | = | 16460.0 | nM | 4.78 |
| CHEMBL5180788 | — | IC50 | = | 16790.0 | nM | 4.78 |
| CHEMBL5190123 | — | IC50 | = | 24820.0 | nM | 4.61 |