Assay Detail
Binding
CHEMBL5140785
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Binding affinity to amyloid beta (1 to 40) (unknown origin) fibrils
20
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid-Beta and Tau Aggregates in Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 16 | 5.33 | 7.41 |
| Ki | 4 | 7.24 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2296467 | — | — | 1 | 8.36 |
| CHEMBL5181356 | — | — | 1 | 7.70 |
| CHEMBL5183943 | — | — | 1 | 7.41 |
| CHEMBL329640 | — | — | 1 | 6.84 |
| CHEMBL57267 | — | — | 1 | 6.05 |
| CHEMBL2203332 | — | — | 1 | 6.03 |
| CHEMBL5193431 | — | — | 1 | 5.95 |
| CHEMBL1314043 | — | — | 1 | 5.92 |
| CHEMBL5204342 | — | — | 1 | 5.72 |
| CHEMBL5182263 | — | — | 1 | 5.37 |
| CHEMBL5197068 | — | — | 1 | 5.20 |
| CHEMBL2207756 | — | — | 1 | 5.08 |
| CHEMBL5196550 | — | — | 1 | 4.88 |
| CHEMBL5177420 | — | — | 1 | 4.84 |
| CHEMBL5179677 | — | — | 1 | 4.48 |
| CHEMBL5175560 | — | — | 1 | 4.41 |
| CHEMBL5171920 | — | — | 1 | 4.04 |
| CHEMBL5195545 | — | — | 1 | - |
| CHEMBL5206461 | — | — | 1 | - |
| CHEMBL5175387 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2296467 | — | Ki | = | 4.38 | nM | 8.36 |
| CHEMBL5181356 | — | Ki | = | 20.2 | nM | 7.70 |
| CHEMBL5183943 | — | Kd | = | 38.69 | nM | 7.41 |
| CHEMBL329640 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL57267 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL2203332 | — | Kd | = | 930.0 | nM | 6.03 |
| CHEMBL5193431 | — | Kd | = | 1130.0 | nM | 5.95 |
| CHEMBL1314043 | — | Kd | = | 1217.0 | nM | 5.92 |
| CHEMBL5204342 | — | Kd | = | 1900.0 | nM | 5.72 |
| CHEMBL5182263 | — | Kd | = | 4290.0 | nM | 5.37 |
| CHEMBL5197068 | — | Kd | = | 6270.0 | nM | 5.20 |
| CHEMBL2207756 | — | Kd | = | 8310.0 | nM | 5.08 |
| CHEMBL5196550 | — | Kd | = | 13100.0 | nM | 4.88 |
| CHEMBL5177420 | — | Kd | = | 14580.0 | nM | 4.84 |
| CHEMBL5179677 | — | Kd | = | 33300.0 | nM | 4.48 |
| CHEMBL5175560 | — | Kd | = | 39300.0 | nM | 4.41 |
| CHEMBL5171920 | — | Kd | = | 92000.0 | nM | 4.04 |
| CHEMBL5195545 | — | Kd | = | 1109000.0 | nM | - |
| CHEMBL5206461 | — | Kd | = | 459000.0 | nM | - |
| CHEMBL5175387 | — | Kd | = | 194000.0 | nM | - |